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IntegrateRNA offers a series of services for transcriptome-wide RNA modification analysis, each designed to accommodate a wide range of sample types and suit your specific research needs, allowing researchers to measure epigenetic profiles of large cohorts at a transcriptome-wide level. We aim to use our advanced NGS platform to accelerate the creation and development of truly and effective RNA medicines.
RNA modifications are emerging players in the field of post-transcriptional regulation of gene expression, and are attracting a comparable degree of research interest to DNA and histone modifications in the field of epigenetics. Currently, more than 100 distinct chemical modifications have been identified in natural RNA, including N6-methyladenosine (m6A), 5-methylcytidine (m5C), inosine (I), N6, 2′-O-dimethyladenosine (m6Am), N1-methyladenosine (m1A), N4-acetylcytidine (ac4C) and N7-methylguanosine (m7G).
Figure1. Chemical modifications in natural RNA
RNA modifications occur at different positions in natural RNA and affect several biological processes. For example, modifications in eukaryotic mRNA can influence the metabolism, function and degradation of mRNA. Modifications in non-coding RNAs are important for maintaining the proper functions of ncRNAs in translation and splicing. Thus, understanding the distributions, regulations, and functions of these RNA modifications will greatly expand our knowledge of epitranscriptomics.
Several epitranscriptome sequencing technologies include MeRIP-seq, RNA-BS-seq, acRIP-seq, m6Am-Exo-seq, miCLIP and direct RNA sequencing have been proposed to preserve RNA modification information and simultaneously transform it into quantitative and measurable signals. These new tools have helped researchers to identify the location of RNA modifications and to reveal these modifications' distinct distribution patterns throughout the transcriptome.
Based on years of experience and professional bioinformatics capability, IntegrateRNA offers sensitive, robust and transcriptome-wide RNA modification detection service to expedite epigenetic research. If you have additional requirements or questions, please feel free to contact us.