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IntegrateRNA offers a transcriptome-wide, efficient and unbiased ac4C detection and location service using ac4C-specific RNA immunoprecipitation with high-throughput sequencing (acRIP-seq) method. Based on advanced NGS platform and experienced bioinformatics professional, we are dedicated to provide a one-stop solution from sample to data.
Chemical modifications of RNA have emerged as a new mechanism for the post-transcriptional regulation of gene expression. Epitranscriptomic modifications, including m6A, m6Am, m1A, pseudouridine, inosine, m5C, m7G and ac4C, have the potential to control all steps of mRNA metabolism including structure, stability, location and translation. One of these modification, N4-acetylcytidine (ac4C), is an ancient and highly conserved RNA modification that is present on tRNA/rRNA and has recently been investigated in eukaryotic mRNA. ac4C helps to correctly read codons during translation and improves translation efficiency and the stability of mRNA. Moreover, recent studies have indicated that ac4C is associated with the development, progression, and prognosis of a variety of human diseases. Thus, a high resolution mapping of ac4C in the transcriptome will help us explore the mechanism by which ac4C triggers the corresponding biological effects.
Figure 1. Schematic diagram of ac4C detection by acRIP-seq
IntegrateRNA is devoted to provide clients with high-quality data for epitranscriptome research. Through a consulting, flexible, integrated and interdisciplinary approach, we provide advice, answers and services to advance your project progress. For further information, please feel free to contact us.