Custom siRNA Synthesis

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Custom siRNA Synthesis

siRNAs are a class of double-stranded RNA molecules that play a role in the RNAi pathway, which interfere with the expression of specific genes and complementary nucleotide sequences by post-transcriptional degradation of mRNA. siRNA can be used as a tool for studying single gene function in vivo and in vitro, and siRNA has attracted attention as a potential therapeutic agent due to its ability to inhibit specific genes in many diseases.

IntegrateRNA, a global biotechnology company specializing in RNA research, has many years of experience in providing professional RNA solutions, high-quality products and services for academic research, biotech research and pharmaceutical drug discovery. With a wide range of modification and purification methods, we are able to provide our clients with custom siRNA synthesis services to meet your research needs. You can submit your targeted siRNA sequence or use our design tools to configure the siRNA sequence. We are committed to providing our customers with the most reliable and effective research services.

Our custom siRNA synthesis services include, but are not limited to

  • siRNA sequence design
  • Design siRNAs that target genes in non-standard species, specific splice variants or homologous regions across gene families or species
  • Deprotected, desalted and ready-to-use
  • Phosphodiester or phosphorothioate backbones available
  • Dye label — a wide range of dye modification combinations for custom fluorescent labeling of siRNA and RNA oligonucleotides are available
  • Fluorescent labeling at the 3' or 5' position of either strand of the siRNA
  • The synthesis of most dye-labeled siRNAs can be extended to grams
  • Chemical modification — In addition to fluorescent dyes, we offer a wide range of other modifications

Our siRNA is a double-stranded RNA molecule consisting of up to 30 bp with a 2 nucleotides 3' overhang and purified by HPLC; siRNA concentration > 97%

Product specifications

  • Guaranteed purity by 85% through CGE measurement
  • Fixed amount is 20 nmol or 40 nmol
  • Sequence length: 17 - 27 bases
  • Quality control of MALDI-TOF MS
  • Delivery: Freeze in a 2 ml screw cap

Although the siRNA oligonucleotide is stable in a 4 °C solution for up to 2 weeks, it is recommended to store the siRNA solution at -20 °C. Aliquots should avoid repeated freezing and thawing. The recommended storage concentration is above 20 μM. The siRNA oligonucleotide stored under the above conditions is stable for at least 6 months. Fluorescently labeled siRNA oligonucleotides must be kept in the dark.

Applications

  • Knock out specific genes of interest to identify gene function
  • Elucidate pathways and screen for potential new drug targets

IntegrateRNA has many years of experience on RNA research and is dedicated to providing comprehensive products and services to a wide range of genomics researchers in the market, including various types of RNA discovery, analysis, and related bioinformatics services. With skilled and experienced genomics experts, we are able to provide our clients with professional and efficient custom siRNA synthesis service to help you design and produce high-purified siRNA sequences. If you have any questions, please feel free to contact us.

For research use only. Not intended for any clinical use.
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