circRNA Sequencing Service

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circRNA Sequencing Service

As one of the leading biotechnology companies, IntegrateRNA is dedicated to providing professional services for circRNA discovery, analysis, and related bioinformatics services. We can help you acquire the circRNA sequence information with single-base resolution at one time through the high-throughput sequencing by strict quality control and advanced bioinformatics analysis. This comprehensive service is designed to provide a one-stop solution and produce the results needed to rapidly advance biological and biomedical research.

A circRNA (circular RNA) is a single-stranded RNA produced by non-sequential reverse splicing of an exon, an intron, or both. circRNA is a highly stable form of non-coding RNA and may be more stable than most linear RNAs in cells because of their nuclease resistance. Recent studies have shown that circRNA has evolutionary conservation in plants, animals, and humans, and has important biological functions. And like many other alternative non-coding isoforms, the biological function of most circRNAs is unclear.

Workflow of circRNA Sequencing Service

Workflow of circRNA Sequencing Service

Different from other small RNAs (like miRNAs), circRNAs are not easy to be separated by size or electrophoretic mobility. In order to construct a circRNA sequencing library, it is first necessary to deplete rRNA, followed by linear RNA digestion and strand-specific library preparation. Our experienced team of experts performs quality management and follows each process to ensure confident and unbiased results.

Bioinformatics Analysis Pipeline

Bioinformatics Analysis Pipeline

In-depth circRNA Data Analysis

  • circRNA analysis: quality control, mapping statistics, etc.
  • Mapping of circRNAs on the genome
  • Statistics of different circRNA types
  • circRNA identification and annotation
  • Known and novel circRNA expression analysis
  • Differential expression analysis, enrichment analysis, and functional analysis
  • Interaction with miRNA and functional analysis of circRNA

Benefits

  • Comprehensive data analysis using widely accepted mainstream software and proven internal pipelines to discover novel circRNAs, differential expressions and functional annotate
  • Data visualization and publication-quality graphics
  • Full service — from sample preparation to results analysis
  • Professional team and efficient operation

IntegrateRNA, a biotechnology company with experienced scientists and advanced sequencing platform, is dedicated to providing the most comprehensive sequencing and data analysis services for circRNA. All of our sequencing services are performed by a group of specially trained and experienced scientists partaking in a streamlined workflow. For further information about our circRNA sequencing service, please feel free to contact us.

For research use only. Not intended for any clinical use.
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